Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay
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چکیده
منابع مشابه
Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay.
Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mouse bone marrow using micronucleus assays. The interaction between THI and genotoxic effects induced by...
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Introduction: Silymarin is obtained from Silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. Silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its...
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This work focuses on the analysis of genotoxic effects on human peripheral lymphocytes exposed in vitro to different arsenic (As) compounds by means of the cytokinesis-block micronucleus assay. The study was carried out by challenging peripheral human lymphocytes with six As compounds in trivalent or pentavalent forms such as arsenite (As(III)) and arsenate (As(V)) and organoarsenic species suc...
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BACKGROUND This research evaluated the genotoxicity of oil and tincture of H. annuus L. seeds using the micronucleus assay in bone marrow of mice. The interaction between these preparations and the genotoxic effects of doxorubicin (DXR) was also analysed (antigenotoxicity test). METHODS Experimental groups were evaluated at 24-48 h post treatment with N-Nitroso-N-ethylurea (positive control -...
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study of the different aspects of protection against the exposure of ionizing radiation has always been an active area of research. high cost and toxicity of radioprotective drugs have limited their use. so, search for new drugs with a high degree of protection and lower cost and side effects seem a necessity. in this study radioprotective effect of aqueous as well as alcoholic extracts of the ...
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ژورنال
عنوان ژورنال: Brazilian Journal of Biology
سال: 2017
ISSN: 1678-4375,1519-6984
DOI: 10.1590/1519-6984.18515